The role of microbes in health and disease

first_imgA new phase of the Human Microbiome Project (HMP)—which over the past five years identified the millions of microorganisms living on, and in, the human body—will focus on the roles played by these microbes both in health and disease. The new three-year “multi-omic” study at the Broad Institute of Harvard and MIT is being co-led by Curtis Huttenhower, associate professor of computational biology and bioinformatics in the Department of Biostatistics at HSPH and an associate member at the Broad.Under the new phase of the HMP, the Broad team will partner with 10 other institutions, including HSPH, to study the microbiomes of healthy people and those with inflammatory bowel disease (IBD)—a set of conditions including Crohn’s disease and ulcerative colitis—with a variety of “omics” techniques, such as proteomic, metabolomics, or transcriptomic analyses. These techniques will help the scientists understand how the microorganisms’ genes operate in disease, and could one day lead to new approaches for managing IBD.“In this phase, we specifically want to understand the biomolecular activity that’s occurring over time, which will require connecting many different data types into network models that capture microbial regulation and metabolism, and their effects on host cells and disease outcome,” said Huttenhower in a November 6, 2013 article on the Broad Institute’s website. Read Full Storylast_img read more

The City of Conversation Extends Off-Broadway Run

first_img Related Shows Jan Maxwell In addition to Maxwell, the cast includes John Aylward, Kristen Bush, Beth Dixon, Barbara Garrick, Luke Niehaus, Kevin O’Rourke, Michael Simpson and Phillip James Brannon. View Comments Directed by Tony winner Doug Hughes, The City of Conversation tells the story of political hostess Hester Ferris (Maxwell), a behind-the-scenes mover and shaker in the nation’s capital, and of the political gains and personal losses that her choices inflict on her family over a period of 30 years, from the waning days of the Carter administration to the beginning of the Obama presidency. Lincoln Center Theater’s production of The City of Conversation has extended its off-Broadway run through July 6. Starring five-time Tony nominee Jan Maxwell, the political drama by Anthony Giardina was originally scheduled to close on June 22. The play celebrated its opening night on May 5. The City of Conversation Show Closed This production ended its run on July 26, 2014 Star Fileslast_img read more